Dr. Md. Rageeb Md. Usman

FORSKOLIN Synonym: Forskohlii, Plectranthusbarbalus. Biological Source: Forskolin is a deterpenes, was obtained from the dried roots of Coleus Forskohlii. Family: Labiatae. Geographical Source: Plants grow perennially over the tropical & subtropical regions including India, Pakistan, Srilanka, Brazil and Tropical East Asia. In India, it occurs at high altitude upto height of 2500m in Himalayas, in the regions from Garhwal, Kumaon to Nepal. It also occurs in Deccan Peninsula and Parasnath Hills in Bihar. Plant Habitat Coleus is a branched, aromatic perennial herb1-2 feet in height leaves have camphor-like flavor with several fasciculate, succulent, radially spread roots about 1000 tonnes of leaves and roots are harvested every year from commercial cultivation in Gujrat. Method of Cultivation: Vegetative method- Stem Cuttings. Harvesting: In the month of autumn. Chemical Constituents Forskolin is a di

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SYLLABUS P 3.6.4. PHARMACOGNOSY –V (PRACTICAL) 1. Laboratory experiments on isolation**, separation, purification** and Spectroscopic analysis* of various groups of chemical constituents of pharmaceutical significance. 2. Estimation of Total flavonoids * * Minor experiments ** Major experiments

SYLLABUS T 3.6.4. PHARMACOGNOSY –V (THEORY) (DURATION: 3 HOURS/WEEK) SECTION-I 1. Chemistry and Spectral Characterization of Simple Natural Origin Molecules Using modern analytical tools (UV, IR, NMR, and Mass). 2. Concept of Stereoisomerism of Natural Products. 3. Introduction , Chemistry, biogenesis and pharmacological activity of medicinally Important Monoterpenes, Sesquiterpenes, Diterpenes, Triterpenoid. 4. Glycosides : Introduction, Chemistry and Biosynthesis of Cardio Active Glycoside (Digitoxin, Digoxin), Sennoside, Diosgenin, Hecogeninand Sarasapogenin. SECTION-I 1. Alkaloids: Introduction, Chemistry, Biogenesis and Pharmacological Activity of Atropine Quinine, Reserpine, Morphine, Papaverine, Ephedrine, Ergot and Vinca alkaloids. Chemistry and Therapeutic Activity of Penicillin, Streptomycin and Tetracycline. 2. Carotenoids: Introduction, α-carotenoids, β-carotenes, vitamin A. 3. Introduction, Chemistry and Biogenesis of Medicinally Important L

SYLLABUS P 3.5.4. PHARMACOGNOSY –IV (PRACTICAL) 1. Morphology*, Microscopic** and powder characteristics* study of eight - selected drugs given in theory. 2. Isolation of total alkaloid (any two) ** 3. Estimation of total alkaloids** 4. TLC study of alkaloids*. 5. Isolation and identification of papain or any one enzymes* 6. Some experiments on plant tissue culture for production of secondary metabolites (Demonstration) a. Preparation of media b. Formation of callus * Minor experiments ** Major experiments

SYLLABUS T 3.5.4. PHARMACOGNOSY –IV (THEORY) (DURATION: 3 HOURS/WEEK) SECTION-I 1. Alkaloids  Introduction, Classification, Physical & Chemical properties, distribution, General extraction methodology of alkaloids.  Biological source, diagnostic features, chemical constituents, chemical tests, uses, adulterants and substituent’s of following. a. Pyridine- Piperidine : Tobacco, Areca and Lobelia. b. Tropane: Belladonna, Hyoscyamus, Datura, Coca. c. Quinoline and Isoquinoline : Cinchona, Ipecac, Opium*. d. Indole : Ergot*, Rauwolfia*, Catharanthus, Nux-vomica and Physostigma. e. Imidazole: Pilocarpus. f. Steroidal : Kurchi, Ashwagandha*. g. Alkaloidal amine : Ephedra and Colchicum. h. Glycoalkaloid : Solanum. i. Purines : Coffee, Tea* and Cola. j. Quinazoline: Vasaka. * Detail Pharmacognostic study of plants. 2. Enzyme Biological Sources, Preparation, Identification Tests and Uses of Diastase, Papain, Pepsin, Trypsin, Pancreatin, streptoki

Schemes for Internal & End Examinationsmacognosy and Phytochemistry-I (Theory) Course Code Name of the Course Internal Assessment End Semester Exams Total Marks Continuous Mode Sessional Exams Total Marks Duration Marks Duration BP 405 T Pharmacognosy and Phytochemistry I (Theory) 10 15 1 Hrs 25 75 3 Hrs 100 Schemes for Continuous Mode Title Mark Attendance 4 Academic activities (Average of any 3 activities e.g. quiz, assignment, open book test, field work, group discussion and seminar) 3 Student – Teacher interaction 3 Total 10 Guideline for Attendance Marks Percentage of Attendance Practical 95 – 100 4 90 – 94